Is a potentiated sulfonamide antibiotic/antimicrobial used to treat certain infections
The combination of trimethoprim and sulfadiazine acts synergistic and usually bactericidal act through inhibition of enzymes in the folic acid pathway, inhibiting thymidine synthesis
Potentiated sulfonamide have a fairly broad spectrum of activity. Gram-positive that are generally affected include streptococci and many strains of staphylococcus, and many Gram-negative bacteria of the family Eentobacteriaceae.
SETRIM most effective in the early stages of acute infections when organisms are rapidly multiplying.
SETRIM is time dependent in their antibacterial efficacy.
SETRIM effective antibacterial concentrations are reached in <1 hr, and peak concentrations in ~4 hr.