Ivermectin is an avermectin and a fermentation product of Streptomyces avermitilis. It’s active against all stages of every major parasitic nematode. It is also a potent ectoparasiticide.Clorsulon is antiparasitic, approved for use in the treatment of immature and adult forms of Fasciola hepatica (Liver fluke) in cattle. Clorsulon inhibits the glycolytic enzymes 3-phosphoglycerate kinase and phosphoglyceromutase, thereby blocking the Emden-Myerh of glycolytic pathway; The fluke is deprived of its main metabolic energy source and dies.
Nitroxynil is a member of Substituted Phenols chemical group and is a fasciolicide which is only active by injection. It’s active against adult fluke, with some activity against fly larvae (e.g. Oestrusovis) and blood sucking nematodes. The mechanism of action is thought to be due to uncoupling of oxidative phosphorylation.
Broad spectrum anthelmintic drugs affect on internal and external parasites.
Has synergistic action on Liver fluke so it affect on mature and immature liver fluke
from 2 weeks old.(instead of 12 weeks old)
action on Fasciola increase from 85% to 99%.
enable the effective control of nematodes in the presence of single or multiple drug resistance
slow the development of anthelmintic resistance to the component anthelmintic classes
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