Streptomycin sulfate is an aminoglycoside antibiotic that has a broad spectrum of antimicrobial (bactericidal) action. The drug is active against Mycobacterium tuberculosis , the majority of gram-negative bacteria ( Escherichia coli , Salmonella spp ., Shigella spp .,Yersinia spp ., Klebsiella spp ., In t. Ch. Klebsiella pneumoniae , Haemophilus influenzae , Neisseria gonorrhoeae , Neisseria meningitidis , Yersinia pestis, Francisella tularensis , Brucella spp .) And some gram-positive microorganisms (Staphylococcus spp., Corynebacterium diphtheria). The bactericidal effect of the drug is due to the binding to the 30S subunit of the bacterial ribosome, which subsequently leads to inhibition of protein synthesis in microorganisms